A guide to
Polynucleotides with Danielle Mae
Polynucleotides are regenerative skin treatments that repair, rejuvenate, and restore your skin from within. They work at a cellular level to improve texture, elasticity, and radiance—reviving tired, ageing, or damaged skin naturally.
Polynucleotides at a glance...
Polynucleotides Treatment – At a Glance:
Treatment time:
30–45 minutes
Anaesthetic:
Topical numbing cream is applied to ensure comfort
Downtime:
Minimal. Mild redness, swelling, or small bumps may be visible for 24–72 hours
Recovery:
Most clients return to normal activities the same day. Skin continues improving over several weeks
When results are seen:
Initial improvements in hydration and skin quality can be seen within 2–3 weeks, with continued regeneration over 6–12 weeks
How many sessions are needed:
A course of 2–3 treatments spaced 3–4 weeks apart is recommended for optimal results
How long results last:
Results typically last 6–9 months, with maintenance treatments advised every 6 months
What it improves:
– Fine lines and wrinkles
– Skin laxity and loss of elasticity
– Dark circles and crepey under-eyes
– Dull, dehydrated, or damaged skin
– Overall skin quality and firmness
How it works:
Polynucleotides stimulate collagen production, improve tissue repair, and enhance hydration by supporting the skin’s natural regenerative processes
Treatment areas:
Face, under-eyes, neck, décolletage, and hands
Polynucleotides are one of the most advanced and exciting innovations in regenerative aesthetics. Derived from purified DNA fragments, these biostimulating molecules work by repairing and rejuvenating the skin’s cellular structure. When injected, they trigger the body’s natural healing processes—stimulating fibroblast activity, boosting collagen and elastin production, improving tissue regeneration, and enhancing hydration deep within the skin. Unlike traditional dermal fillers that simply add volume, polynucleotides work on a deeper biological level to restore the skin’s quality and function over time. They improve elasticity, firmness, and luminosity while reducing fine lines, inflammation, and signs of fatigue. The result is a healthier, more youthful complexion that continues to improve in the weeks following treatment. Polynucleotides are suitable for both men and women looking for a subtle, natural enhancement. They’re particularly effective for those experiencing dullness, loss of elasticity, fine lines, under-eye crepiness, acne scarring, or sun damage. Treatments can be used alone or combined with other regenerative therapies such as PRF, skin boosters, or microneedling to further amplify results. Because they work with your body’s own repair mechanisms rather than masking imperfections, polynucleotides are ideal for anyone seeking a science-led, holistic approach to skin rejuvenation—one that enhances long-term skin health and radiance rather than temporary correction.
Describe your image
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A personal note....
I’ve fallen in love with polynucleotides because they represent everything I value in aesthetics—science, subtlety, and true skin healing. Over the years, I’ve seen so many clients who want to rejuvenate their skin but are hesitant about looking “done.” Polynucleotides are the perfect answer. They don’t alter your natural features; they simply help your skin remember how to function optimally again. For me, this treatment bridges the gap between clinical precision and holistic rejuvenation—it’s regenerative beauty at its finest. Watching my clients’ skin transform week by week, becoming smoother, fresher, and more alive, is such a joy. It’s not just about looking better—it’s about helping your skin feel better from within. Danielle x
